RISE IN PEDIATRIC MYOCARDITIS
Clinical studies and public reports indicate a recent national rise in Acute MYOCARDITIS cases in children and teens with the risk as high as 35+ times for children infected with Covid-19. [1][2] Scientific statements by the AHA indicate that viral infection is the #1 cause of inflammation in the heart muscle (the myocardium) weakening the heart's performance and electrical system. Severe cases can result in abnormal heart rhythms, heart failure or shock. Minimally or non-invasive testing is available to detect the presence of myocarditis including blood tests or medical imaging to scan for visible injury to the heart muscle or abnormalities in heart function (pericarditis) [3]. It is recommended to maintain regular checkups for children and watch for sudden fatigue, shortness of breath, fever, chest pain and palpitations.
COVID-19 MYOCARDITIS
Viral infection may be inferred by the common dermatologic manifestations of Covid-19 rash on the digits of the fingers and toes. Imaging with optical technologies and ultrasound may verify vascular occlusion or inflammatory vasculitis typical of this multifactorial disorder. [4*]
MORBIDITY IN CHILDREN & THE 2022 NATIONAL ADVOCACY
Under a 2019 study by the University Clinical Center of Kosovo indicated that myocarditis is the cause of sudden death in the pediatric community- resulted from "inflammatory infiltrates that act as arrhythmogenic foci, leading to fatal arrhythmia. Studies of sudden infant death syndrome have linked infection with viruses such as enterovirus, adenovirus, parvovirus B19, and Epstein-Barr virus and myocarditis to sudden infant death syndrome victims"[5]. Acute myocarditis is most prevalent with viral causes- often shown by polymerase chain reaction (PCR) analysis of myocardial tissue. Noninfectious causes of myocarditis include autoimmunity, hypersensitivity, medications, and toxins [6]. A wide set of reactions include mild symptoms to severe heart failure. Partial or full clinical recovery is reported in a few days to advanced low cardiac output syndrome requiring mechanical circulatory support or heart transplantation. Pediatric myocarditis remains challenging from the perspectives of diagnosis and management.
STANDARDIZED DIAGNOSTICS
As with any critical disorder, detecting early stages of myocarditis can allow for higher opportunity to manage, reduce or even prevent the health risk. In children and young athletes, symptoms may include: Breathing issues, Fever, Fainting, Chest pressure/pain and Rapid/irregular heart rhythms. In adults, symptoms range from chest pain, shortness of breath, at rest or during activity and fluid buildup with swelling of the legs, ankles and feet. To prevent possible heart damage, a cardiologist may order one of a number of imaging options. [7] [8] [9]
▪ Heart MRI (Cardiac MRI). A cardiac MRI shows your heart's size, shape and structure. This test can show signs of inflammation of the heart muscle. [10]
▪ Electrocardiogram (ECG or EKG). This quick and painless test shows your heart's electrical patterns and can detect irregular heartbeats. [11]
▪ Chest X-Ray: An X-ray image shows the size and shape of your heart, as well as whether you have fluid in or around the heart that might be related to heart failure. [12]
▪ Blood Tests: There are no specific blood tests to confirm the diagnosis of myocarditis; however, an otherwise unexplained elevation in troponin (a blood test that indicates heart muscle damage) and/or electrocardiographic features of cardiac injury are supportive [13]. Blood tests for Troponins (proteins in the blood which are released when the heart muscle has been damaged), BNP (a blood test that measures levels of a protein that is made by your heart and blood vessels.) [14]
▪ Doppler Ultrasound for Acute Myocarditis: Another diagnostic solution that's made available for bedside imaging of poor cardiac contractility from myocarditis and pericardial effusion is the use of a Point of Care Ultrasound. Case reports demonstrate the estimation of left ventricular function abnormalities [15]. Other advanced studies employing Contrast-enhanced ultrasound and molecular imaging have been used to can detect endothelial inflammation in the left ventricle [16].
▪ Cardiovascular MR Elastography (MRE): Classical MRE uses an external mechanical transducer to assess the viscoelastic properties of cardiac soft tissues which is technically difficult in an MR suite due to probe placement and ECG lead distribution. Using the wave genereted by the valve closure is now possible. [17*]
▪ Ultrasound Elastography: Elastography for tissue plasticity has been used worldwide for 15 years and recent studies have reported myocardial stiffness expressed in kilopascal (kPa) instead of shear wave velocity. Vibrations related to aortic valve closure generated MR detectable data allowing clinical data at multiple depths in the pediatric patient which was difficult in the adult subject. [18*][19*]
CLICK for References. All (*) marked with asterisk are textbook based (non-web) references and are avaiable below this page.
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